Gene info
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBa; through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
Gene names
PNP1, PTP1E, PTPL1, Tyrosine-protein phosphatase non-receptor type 13, Fas-associated protein-tyrosine phosphatase 1, FAP-1, PNP1, PTPLE, PTP-BL, hPTP1E, PTP-BAS, Proteintyrosine phosphatase
Antibodie's label
unlabelled serum
