Cantharidin, Phosphatase PP2A inhibitor

Size

20 mg

Catalog No

SIH-519-20MG

Price

108€

Stock availabilitIn Stock

In Stock

CAS number

56-25-7

Description

Phosphatase PP2A inhibitor

Cantharidin, Phosphatase PP2A inhibitor

Molecular weight

196,2 g/mol

Primary research fields

Cell Signaling

Other name

3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione

Cantharidin, Phosphatase PP2A inhibitor

Product category

Small Molecules

Product type

Inhibitor

Chemical formula

C10H12O4

Cantharidin, Phosphatase PP2A inhibitor

Origin

Synthetic

Purity pourcentage

≥98% (GC)

Soluble in

Soluble in DMSO or 100% ethanol

Cantharidin, Phosphatase PP2A inhibitor

Physical appearance

White to off-white solid

Storage recommendations

-20ºC

Shipping recommendations

Shipped Ambient

Cantharidin, Phosphatase PP2A inhibitor

Safety information

Classification: Acute toxicity, Oral (Category 2), H300 Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300 Fatal if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ containerto an approved waste disposal plant.

PubChem number

2545

Scientific context

Cantharidin is an inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). It is a naturally occurring toxin found in Mylabris phalerata.

Cantharidin, Phosphatase PP2A inhibitor

Bibliography

1. Honkanen R. E. (1993) FEBS Letters. 330(3): 283–286. 2. Eldridge R., & Casida J.E. (1995) Toxic. App. Pharm. 130(1): 95–100.

Release date

1-Oct-2014

PubMed number

Refer to PubMed

Cantharidin, Phosphatase PP2A inhibitor

Tested applications

To be tested

Tested reactivity

To be tested

Representative figure legend

Chemical structure of Cantharidin (SIH-519), a Phosphatase PP2A inhibitor. CAS #: 56-25-7. Molecular Formula: C10H12O4. Molecular Weight: 196.2 g/mol. Chemical structure of Cantharidin, a Phosphatase PP2A inhibitor (SIH-519). CAS # 56-25-7. Molecular Formula: C10H12O4.

Cantharidin, Phosphatase PP2A inhibitor

Warning information

Non-hazardous

Country of production

Canada

Total weight (kg)

0.25

Cantharidin, Phosphatase PP2A inhibitor

Net weight (g)

0.02

Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Cantharidin, Phosphatase PP2A inhibitor