Stock availabilitIn Stock
In Stock
CAS number
56-25-7
Description
Phosphatase PP2A inhibitor
In Stock
56-25-7
Phosphatase PP2A inhibitor
196,2 g/mol
Cell Signaling
3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
Small Molecules
Inhibitor
C10H12O4
Synthetic
≥98% (GC)
Soluble in DMSO or 100% ethanol
White to off-white solid
-20ºC
Shipped Ambient
Classification: Acute toxicity, Oral (Category 2), H300 Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300 Fatal if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ containerto an approved waste disposal plant.
2545
Cantharidin is an inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). It is a naturally occurring toxin found in Mylabris phalerata.
1. Honkanen R. E. (1993) FEBS Letters. 330(3): 283–286. 2. Eldridge R., & Casida J.E. (1995) Toxic. App. Pharm. 130(1): 95–100.
1-Oct-2014
Refer to PubMed
To be tested
To be tested
Chemical structure of Cantharidin (SIH-519), a Phosphatase PP2A inhibitor. CAS #: 56-25-7. Molecular Formula: C10H12O4. Molecular Weight: 196.2 g/mol. Chemical structure of Cantharidin, a Phosphatase PP2A inhibitor (SIH-519). CAS # 56-25-7. Molecular Formula: C10H12O4.
Non-hazardous
Canada
0.25
0.1
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
