Size

50 μg

Catalog No

X2779B

Price

168€

Buy: PINK1 - Blocking Peptide

Long description

This peptide is the immunogen used to make Cat # X2764P. _x000B__x000B_Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

Antibody come from

Synthetic peptide corresponding to amino acids 246-265 derived from the carboxyl terminal of the canine SRbeta subunit.

Other description

Provided as solution in phosphate buffered saline with 0.08% sodium azide.

Clone

not specified

Antigen-antibody binding interaction

PINK1 - Blocking Peptide

Antibody is raised in

see techfile

Antibody's reacts with

Blocking Peptide to Cat # X2764P

Antibody's reacts with these species

This antibody doesn't cross react with other species

Antibody's specificity

No Data Available

Application

Blocking Peptide

Antibody's suited for

Detects SRbeta by Western blot analysis at 15 µg/ml. Antibody will not detect SRbeta protein bound to SRalpha. Optimal concentration should be evaluated by serial dilutions.

Storage

-20ºC

Relevant references

1. Bacher, G., et al. The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor. J. Cell. Biol. 1999, 146, 723-730._x000B__x000B_2. Ogg SC, et al. A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit. J. Cell. Biol. 1998, 142, 341-354._x000B__x000B_3. Young, J.C., et al. An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane. J. Biol. Chem. 1995, 270, 15650-15657._x000B_

Protein number

see ncbi

Warnings

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.

Test

You can block the antibody by the specific target amino acid sequence of peptide.

Properties

blocking peptide

Description

Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.