Rabbit anti PINK1

Size

100 μg

Catalog No

X2764P

Price

420€

Category

Primary Antibodies

Long description

Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

Antibody come from

Hybridoma produced from mice immunized with human peripheral blood mononuclear cells.

Rabbit anti PINK1

Other description

Provided as solution in phosphate buffered saline with 0.08% sodium azide. Antigen Immunoaffiinity Purification

Clone

Polyclonal

Antigen-antibody binding interaction

Rabbit anti PINK1 Antibody

Rabbit anti PINK1

Antibody is raised in

Rabbit

Antibody's reacts with

Human

Antibody's reacts with these species

This antibody doesn't cross react with other species

Rabbit anti PINK1

Antibody's specificity

No Data Available

Application

Western blot, Immunohistochemistry, EIA

Antibody's suited for

Antibody can be used for Western blotting (1-10 µg/ml), Immunoprecipitation (1-2 µg per 100-500 µg of total protein), Immunofluorescence (2-20ʵg/ml), Immunohistochemistry (2-20 µg/ml). Optimal concentration should be evaluated by serial dilutions.

Rabbit anti PINK1

Storage

-20ºC

Relevant references

Abo, T., et al. J. Immuno., 127, 1024 (1984)

Protein number

see ncbi

Rabbit anti PINK1

Warnings

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

About

Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.

Rabbit anti PINK1

Latin name

Oryctolagus cuniculus

Rabbit anti PINK1