Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
liquid
Immunogen affinity purified
≥95% as determined by SDS-PAGE
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
phosphatase and tensin homolog
MMAC1, TEP1
55 kDa
P60484
Human, Mouse, Rat, Monkey
ELISA, WB, IHC
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Immunohistochemistry of paraffin-embedded human breast hyperplasia tissue slide using FNab09821( PTEN Antibody) at dilution of 1:600
fetal human brain tissue were subjected to SDS PAGE followed by western blot with FNab09821( PTEN Antibody) at dilution of 1:1000
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody for research use.
If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
anticorps
