Immunogen
A synthesized peptide derived from human TRAF6
Antibody's target
Human TRAF6
Antibody's full description
Rabbit Anti-Human TRAF6 Polyclonal
100 µl
SPC-1316D-ALP
350€
A synthesized peptide derived from human TRAF6
Human TRAF6
Rabbit Anti-Human TRAF6 Polyclonal
Polyclonal Antibodies
E3 ubiquitin-protein ligase TRAF6 Antibody, Interleukin 1 signal transducer Antibody, Interleukin-1 signal transducer Antibody, MGC 3310 Antibody, MGC:3310 Antibody, MGC3310 Antibody, OTTHUMP00000232772 Antibody, OTTHUMP00000232773 Antibody, RING finger protein 85 Antibody, RNF 85 Antibody, RNF85 Antibody, TNF receptor associated factor 6 Antibody, TNF receptor-associated factor 6 Antibody, TNF receptor-associated factor 6, E3 ubiquitin protein ligase Antibody, TRAF 6 Antibody, Traf6 Antibody, TRAF6_HUMAN Antibody
WB, IHC
Rabbit
Human, Mouse, Rat
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
See included datasheet or contact our support service
Detects ~58kDa, endogenous levels of total TRAF6
-20°C
Blue Ice or 4°C
A 1:1000 dilution of SPC-1316 was sufficient for detection of TRAF6 in 10 µg of mouse brain cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cytoplasm, Cell Cortex, Nucleus
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
TNF receptor-associated factor 6 is a member of the TNF receptor associated factor (TRAF) protein family. TNF receptor-associated factor 6 proteins play an important role as adaptor protein for cell survival, proliferation, differentiation and stress responses. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.
1. Nishitoh H. et al. (1998) Mol. Cell 2 (3): 389–95. 2. Hoeflich KP et al. (1999) Oncogene 18 (42): 5814–20. 3. Mochida Y. et al. (2000) J. Biol. Chem. 275 (42): 32747–52.
6/Sep/2016
NP_665802.1
7189
Q9Y4K3
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus