Immunogen
A synthesized peptide derived from human RAGE
Antibody's target
Human RAGE
Antibody's full description
Rabbit Anti-Human RAGE Polyclonal
100 µl
SPC-1292D-ALP
350€
A synthesized peptide derived from human RAGE
Human RAGE
Rabbit Anti-Human RAGE Polyclonal
Cardiovascular System, Atherosclerosis, Neuroscience, Neurodegeneration, Alzheimer’s Disease
Polyclonal Antibodies
Advanced glycosylation end product-specific receptor Antibody, Ager Antibody, MGC2235 Antibody, RAGE_HUMAN Antibody, Receptor for advanced glycosylation end products Antibody
WB, IHC, ICC/IF
Rabbit
Human
WB (1:1000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
See included datasheet or contact our support service
Detects ~42kDa, endogenous levels of total RAGE.
-20°C
Blue Ice or 4°C
A 1:1000 dilution of SPC-1292 was sufficient for detection of RAGE in 10 µg of human brain cell lysates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cell Membrane, Secreted
Endothelial cells.
RAGE, the receptor for advanced glycation endproducts, is a 35 kDa transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. It is also called "AGER". The increased expression of RAGE is associated with many disorders, such as diabetic vasculopathy, neuropathy, retinopathy and neuropathy, Alzheimer’s disease and immune/inflammatory reactions of the vessel walls. It is reported that RAGE along with Amphoterin stimulates myoblast differentiation by the combined effect of stimulation of differentiation and inhibition of proliferation, and deregulation of RAGE expression in myoblasts might contribute to their neoplastic transformation.
1. Neeper M. et al. (1992) The Journal of Biological Chemistry 267 (21): 14998–5004. 2. Bierhaus A. et al. (2001) Diabetes 50 (12): 2792–808. 3. Hudson BI. et al. (2001) Diabetes 50 (6): 1505–11.
6/Sep/2016
NP_001127.1
177
Q15109
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus
