Immunogen
Synthetic peptide of human Ret (AA177-191)
Antibody's target
Human RET
Antibody's full description
Rabbit Anti-Human RET Polyclonal
100 µl
SPC-1196D-ALP
391€
Synthetic peptide of human Ret (AA177-191)
Human RET
Rabbit Anti-Human RET Polyclonal
Polyclonal Antibodies
C ret antibody, Cadherin family member 12 antibody, Cadherin related family member 16 antibody, CDHF 12 antibody, CDHF12 antibody, CDHR16 antibody, HSCR 1 antibody, Hydroxyaryl protein kinase antibody, MEN2A antibody, MEN2B antibody, MTC 1 antibody, MTC1 antibody, Multiple endocrine neoplasia and medullary thyroid carcinoma 1 antibody, Oncogene RET antibody, PTC antibody, RET antibody, RET ELE1 antibody, Ret Proto oncogene antibody, RET transforming sequence antibody, RET_HUMAN antibody, RET51 antibody, RET9 antibody, tyrosine-protein kinase receptor ret antibody
WB, AM
Rabbit
Human
WB (1:250); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
See included datasheet or contact our support service
Detects 124.319 kDa.
-20°C
Blue Ice or 4°C
A 1:250 dilution of SPC-1196 was sufficient for detection of RET in 10 µg of human A549 cell line lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Cell Membrane
See included datasheet or contact our support service.
RET is a receptor-tyrosine kinase that is activated upon binding glial-derived neurotrophic factor (GDNF). Normally involved in the differentiation of neural crest cells and organs (salivary glands, spleen, thyroid, thymus etc). Given its vary clearly identified role in thyroid carcinoma and also the known oncogenic potential of RTKs, it is not surprising that this gene is characterized as a proto-oncogene. Fusion partners result in disregulated kinase activity related both to constituent activation and promiscuous protein interaction.
Refer to PubMed
29/Aug/2016
NP_066124
5979
P07949
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus