Immunogen
Synthetic peptide of human Abl1 (AA1110-1123)
Antibody's target
Human Abl1
Antibody's full description
Rabbit Anti-Human Abl1 Polyclonal
100 µl
SPC-1099D-ALP
391€
Synthetic peptide of human Abl1 (AA1110-1123)
Human Abl1
Rabbit Anti-Human Abl1 Polyclonal
Polyclonal Antibodies
Abelson murine leukemia viral oncogene homolog 1 antibody, Abelson tyrosine protein kinase 1 antibody, Abl 1 antibody, ABL antibody, ABL proto oncogene 1 non receptor tyrosine kinase antibody, ABL1 antibody, c ABL antibody, c abl oncogene 1 receptor tyrosine kinase antibody, JTK7 antibody, p150 antibody, Proto oncogene tyrosine protein kinase ABL1 antibody, Tyrosine-protein kinase ABL1 antibody, v abl antibody
WB, AM
Rabbit
Human
WB (1:250); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
See included datasheet or contact our support service
Detects 122.945 kDa.
-20°C
Blue Ice or 4°C
A 1:250 dilution of SPC-1099 was sufficient for detection of Abl1 in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Cytoplasm, Cytoskeleton, Nucleus
Widely expressed.
ABL1 is a widely-expressed, non-receptor protein-tyrosine kinase. It is stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. It is activated by autophosphorylation as well as by Src-family kinase-mediated phosphorylation. It can also be activated by RIN1 binding to the SH2 and SH3 domains. As it is stimulated by cell death inducers and DNA-damage, it is likely that the wild-type form of Abl1 is actually a tumour -suppressor protein. The normal active form of Abl1 is nuclear, and it is sequestered into the cytoplasm by interaction with 14-3-3 through Thr-735. It localizes to the mitochondria under conditions of oxidative stress.
Refer to PubMed
29/Aug/2016
NP_005148
25
P00519
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus