Immunogen
A phospho-specific peptide corresponding to residues surrounding Ser677 of human TTK (AA674-680)
Antibody's target
Human TTK (pSer677)
Antibody's full description
Rabbit Anti-Human TTK (pSer677) Polyclonal
100 µl
SPC-1091D-ALP
391€
A phospho-specific peptide corresponding to residues surrounding Ser677 of human TTK (AA674-680)
Human TTK (pSer677)
Rabbit Anti-Human TTK (pSer677) Polyclonal
Polyclonal Antibodies
Dual specificity protein kinase TTK Antibody, ECSTY kinase Antibody, ESK Antibody, FLJ38280 Antibody, hMPS1 Antibody, Monopolar Spindle 1 Like 1 Antibody, MPH1 Antibody, Mps 1 Antibody, MPS1L1 Antibody, Phosphotyrosine Picked Threonine Kinase Antibody, Phosphotyrosine picked threonine-protein kinase Antibody, PYT Antibody, RP3-357D13.2 Antibody, ttk Antibody, TTK Protein Kinase Antibody, TTK_HUMAN Antibody, cancer/testis antigen 96 Antibody, CT96 Antibody
WB, AM
Rabbit
Human
WB (1:250); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
See included datasheet or contact our support service
Detects 97.072 kDa.
-20°C
Blue Ice or 4°C
A 1:250 dilution of SPC-1091 was sufficient for detection of TTK (pSer677) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Membrane, Cytoskeleton, Spindle
Expressed in rapidly proliferating cell lines.
TTK is a dual-specificity protein kinase with activity toward serine, threonine and tyrosine residues. TTK was found to have a role in cell cycle progression through regulating centrosome duplication during S-phase. This function was CDK2-mediated by direct activation of TTK. Overexpression or dysregulation of TTK activtiy may promote cancer through aberrant duplication of centrosomes and promotiong of aneuploidy. Mutations in TTK are highly correlated in the development of microsatellite-unstable colorectal cancers. These mutations were typically loss of function frameshift truncation, however the functional relevance of the mutation was still not determined.
Refer to PubMed
29/Aug/2016
NP_003309
7272
P33981
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus