Immunogen
A phospho-specific peptide corresponding to residues surrounding Ser439 of human TAK1 (AA436-442)
Antibody's target
Human TAK1 (pSer439)
Antibody's full description
Rabbit Anti-Human TAK1 (pSer439) Polyclonal
100 µl
SPC-1086D-ALP
391€
A phospho-specific peptide corresponding to residues surrounding Ser439 of human TAK1 (AA436-442)
Human TAK1 (pSer439)
Rabbit Anti-Human TAK1 (pSer439) Polyclonal
Polyclonal Antibodies
M3K7_HUMAN Antibody, MAP3K 7 Antibody, Map3k7 Antibody, MEKK7 Antibody, Mitogen activated protein kinase kinase kinase 7 Antibody, Mitogen-activated protein kinase kinase kinase 7 Antibody, TAK1 Antibody, TGF beta activated kinase 1 Antibody, TGF-beta-activated kinase 1 Antibody, TGF1a Antibody, Transforming growth factor beta activated kinase 1 Antibody, Transforming growth factor-beta-activated kinase 1 Antibody
WB, AM
Rabbit
Human
WB (1:250); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
See included datasheet or contact our support service
Detects 67.196 kDa.
-20°C
Blue Ice or 4°C
A 1:250 dilution of SPC-1086 was sufficient for detection of TAK1 (pSer439) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Cytoplasm, Cell Membrane
Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.
TAK1 encoded by the gene MAP3K7, is a protein-serine/threonine kinase that is activated by proinflammatory cytokines and in response to physical/chemical stress, including UVR, osmotic- and oxidative stress. It is a mediator of TRAF6 and TGF-β signal transduction, and activates IKBKB and MAPK8 in response to TRAF6 signalling. It also stimulates NFκB activation and activation of the p38 MAPK pathway. It is responsible for controlling a variety of cell functions such as transcription and apoptosis. TAK1 is important for TGF-β1 regulation of MMP9 and the metastatic potential of certain breast cancer cell lines.
Refer to PubMed
29/Aug/2016
NP_663304
6885
O43318
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus