Immunogen
A phospho-specific peptide corresponding to residues surrounding Tyr645 and Tyr646 of human ROR2 (AA642-649)
Antibody's target
Human ROR2 (pTyr645 + pTyr646)
Antibody's full description
Rabbit Anti-Human ROR2 (pTyr645 + pTyr646) Polyclonal
100 µl
SPC-1075D-ALP
391€
A phospho-specific peptide corresponding to residues surrounding Tyr645 and Tyr646 of human ROR2 (AA642-649)
Human ROR2 (pTyr645 + pTyr646)
Rabbit Anti-Human ROR2 (pTyr645 + pTyr646) Polyclonal
Polyclonal Antibodies
NTRKR2 Antibody, Receptor tyrosine kinase-like orphan receptor 2 Antibody, receptor-related 2 Antibody, ROR2 Antibody, ROR2_HUMAN Antibody, Tyrosine protein kinase transmembrane receptor ROR2 Antibody, Tyrosine-protein kinase transmembrane receptor Ror2 Antibody, BDB Antibody, BDB1 Antibody, Brachydactyly type B Antibody, EC 2.7.10.1 Antibody, MGC163394 Antibody, Neurotrophic tyrosine kinase Antibody, Neurotrophic tyrosine kinase, receptor related 2 Antibody
WB, AM
Rabbit
Human
WB (1:250); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
See included datasheet or contact our support service
Detects 104.757 kDa.
-20°C
Blue Ice or 4°C
A 1:250 dilution of SPC-1075 was sufficient for detection of ROR2 (pTyr645 + pTyr646) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Cell Membrane
Highly expressed during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
ROR2 is a receptor tyrosine kinase which may have a role in early cartilage and growth plate development. ROR2 expression is generally highest during embryonic development and will gradually decrease as cells terminally differentiate. Wnt5a has been identified to utilize ROR2 as a co-receptor for non-canonical Wnt signalling. Aberrant expression of ROR2 has been implicated in gastric, osteosarcoma, mestatic melanoma, prostate, renal cell and squamous cell carcinomas. Increased expression of ROR2 was correlated with increased metastasis. In prostate, osteosarcomas and metastatic melanomas, Wnt5a/ROR2 receptor complex formation was implicated as the mechanism for cancer progression. ROR2 seems to function as an oncogene. Primarily mis-sense mutations of ROR2 have been identified in tumours but their functional effect has not been well characterized.
Refer to PubMed
29/Aug/2016
NP_004551
4920
Q01974
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus