Immunogen
A phospho-specific peptide corresponding to residues surrounding Thr161 and Thr162 of human MLTK (AA158-165)
Antibody's target
Human ZAK (pThr161+pThr162)
Antibody's full description
Rabbit Anti-Human ZAK (pThr161+pThr162) Polyclonal
100 µl
SPC-1029D-ALP
391€
A phospho-specific peptide corresponding to residues surrounding Thr161 and Thr162 of human MLTK (AA158-165)
Human ZAK (pThr161+pThr162)
Rabbit Anti-Human ZAK (pThr161+pThr162) Polyclonal
Polyclonal Antibodies
AZK antibody, Cervical cancer suppressor gene 4 protein antibody, HCCS 4 antibody, HCCS-4 antibody, Human cervical cancer suppressor gene 4 protein antibody, Leucine zipper and sterile alpha motif containing kinase antibody, Mitogen activated protein kinase kinase kinase MLT antibody, Mixed lineage kinase related kinase antibody, MLK 7 antibody, MLK related kinase antibody, MLK-like mitogen-activated protein triple kinase antibody, MLK-related kinase antibody, MLK7 antibody, Mlklak antibody, MLT antibody, MLTK_HUMAN antibody, ZAK antibody
WB, AM
Rabbit
Human
WB (1:250); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
See included datasheet or contact our support service
Detects 91.181 kDa.
-20°C
Blue Ice or 4°C
A 1:250 dilution of SPC-1029 was sufficient for detection of ZAK (pThr161+pThr162) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Cytoplasm, Nucleus
Ubiquitously expressed
Stress activated and proapoptotic member of the MAPKKK family. Regulates the JNK and p38 pathways. Involved in regulation of S and G2 cell cycle checkpoints by direct phosphorylation of CHEK2. MLTK causes cell shrinkage and disruption of actin stress fibers and phosphorylates histone H3 (Ser-28). It was suggested to play a role in cell transformation and oncogenesis.
Refer to PubMed
29/Aug/2016
NP_057737
51776
Q9NYL2
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus