Immunogen
A phospho-specific peptide corresponding to residues surrounding Thr179 and Ser180 of human IKKa (AA177-184)
Antibody's target
Human IKKa (pThr179+pSer180)
Antibody's full description
Rabbit Anti-Human IKKa (pThr179+pSer180) Polyclonal
100 µl
SPC-998D-ALP
391€
A phospho-specific peptide corresponding to residues surrounding Thr179 and Ser180 of human IKKa (AA177-184)
Human IKKa (pThr179+pSer180)
Rabbit Anti-Human IKKa (pThr179+pSer180) Polyclonal
Polyclonal Antibodies
Chuk Antibody, CHUK1 Antibody, Conserved Helix Loop Helix Ubiquitous Kinase Antibody, I Kappa B Kinase 1 Antibody, IkB kinase alpha subunit Antibody, IkBKA Antibody, IKK 1 Antibody, IKK A Antibody, IKKA Antibody, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells Antibody, NFKBIKA Antibody, Nuclear Factor Kappa B Inhibitor Kinase Alpha Antibody, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor Antibody, TCF16 Antibody, Transcription factor 16 Antibody
WB, AM
Rabbit
Human
WB (1:250); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
See included datasheet or contact our support service
Detects 84.654 kDa.
-20°C
Blue Ice or 4°C
A 1:250 dilution of SPC-998 was sufficient for detection of IKKa (pThr179+pSer180) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Cytoplasm, Nucleus
Widely expressed.
IKKa is a protein-serine/threonine kinase. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Loss of function therefore blunts the NF-kB response. Cells with DNA damage are unable to undergo apoptosis. Oncogenesis may therefore occur indirectly by inhibitting a downstream tumour suppresor (inhibitors of NF-kB).
Refer to PubMed
29/Aug/2016
NP_001269
1147
O15111
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus