Immunogen
A phospho-specific peptide corresponding to residues surrounding Ser193 of human Aurora C (AA190-196)
Antibody's target
Human Aurora C (pSer193)
Antibody's full description
Rabbit Anti-Human Aurora C (pSer193) Polyclonal
100 µl
SPC-921D-ALP
391€
A phospho-specific peptide corresponding to residues surrounding Ser193 of human Aurora C (AA190-196)
Human Aurora C (pSer193)
Rabbit Anti-Human Aurora C (pSer193) Polyclonal
Polyclonal Antibodies
AURKC Antibody, AIE2 Antibody, ARK3 Antibody, Aurora/lpl1 related kinase 3 Antibody, Serine threonine protein kinase 13 Antibody, STK13 Antibody, SPGF5 Antibody, IPL-1/STK13/Aurora C Antibody
WB, AM
Rabbit
Human
WB (1:250); optimal dilutions for assays should be determined by the user.
Peptide Affinity Purified
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
See included datasheet or contact our support service
Detects 35.591 kDa.
-20°C
Blue Ice or 4°C
A 1:250 dilution of SPC-921 was sufficient for detection of Aurora C (pSer193) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Chromosome, Cytoplasm, Cytoskeleton
See included datasheet or contact our support service.
Aurora C is part of the larger AURA family of serine/threonine kinases and is a key regulator of mitotic cell division. It is involved in regulating microtubule formation and the assembly of the mitotic spindle responsible for chromosome segragation during mitosis. AURA activity is cell cycle dependent with the greatest activity occuring during mitosis. The overexpression of AURA has been well documented in many malignant cancers including breast, ovarian, colon, prostate and neuroblastomas. Overexpression of AURA appears to override checkpoints in cell cycle progression leading to increased cell division and proliferation.
Refer to PubMed
29/Aug/2016
NP_001015878
6795
Q9UQB9
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
No Data Available
Non-hazardous
Canada
1.4
0.1
In Stock
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Oryctolagus cuniculus