Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Immunogen

A phospho-specific peptide corresponding to residues surrounding Tyr439 and Thr440 of human Abl2 (AA3437-443)

Antibody's target

Human Abl2 (pTyr439 + pThr440)

Antibody's full description

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Antibody's category

Polyclonal Antibodies

Antibody's other name

Abelson tyrosine protein kinase 2 Antibody, ABL2 Antibody, ARG Antibody, Tyrosine kinase ARG Antibody

Verified applications

WB, AM

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Raised in

Rabbit

Antibody's reactivity

Human

Antibody's recommended dilutions for use

WB (1:250); optimal dilutions for assays should be determined by the user.

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Antibody's purified from

Peptide Affinity Purified

Recommended buffer for storage

PBS pH7.4, 50% glycerol, 0.025% Thimerosal

Antibody's concentration

See included datasheet or contact our support service

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Antibody's specificity

Detects 128.343 kDa.

Storage recommendations

-20°C

Shipping recommendations

Blue Ice or 4°C

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Certificate of analysis

A 1:250 dilution of SPC-906 was sufficient for detection of Abl2 (pTyr439 + pThr440) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Antibody in cell

Cytoplasm, Cytoskeleton

Tissue specificity

Widely expressed

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Scientific context

ABL2 (Arg) is a widely expressed, 128 kDa, non-receptor protein-tyrosine kinases that is structurally related to Abl1. It features SH3 and SH2 domains, a protein- tyrosine kinase domain, and a nuclear localization domain. It shares many functions with Abl1, which includes cytoskeleton remodelling through phosphorylation of enzymes responsible for cytoskeleton rearrangements for signalling, adhesion, and movement as well as microtuble subunits, TUBA1 and TUBB. It also contains F-actin binding region to bundle and regulate actin cytoskeletal structure. It possesses autocatalytic activity and the ability to phosphorylate its inhibitor ABI1 to regulate itself.

Bibliography

Refer to PubMed

Released date

29/Aug/2016

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

NCBI number

NP_009298

Gene number

27

Protein number

P42684

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

PubMed number

Refer to PubMed

Tested applications

To be tested

Tested reactivity

To be tested

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Antibody's datasheet

Contact our support service to receive datasheet or other technical documentation.

Representative figure link

No Data Available

Warning information

Non-hazardous

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Country of production

Canada

Total weight (kg)

1.4

Net weight (g)

0.1

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Stock availabilit

In Stock

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Test

StressMark antibodies supplies antibodies that are for research of human proteins.

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Group

Polyclonals and antibodies

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase

Latin name

Oryctolagus cuniculus

Rabbit Anti-Human Abl2 (pTyr439 + pThr440) Polyclonal: Alkaline Phosphatase