Size

50µg

Catalog No

PKSH032459-50µg

Price

577€

Buy: Recombinant Human Fructose-2,6-Bisphosphatase 1/PFKFB1/PFK/FBPase 1 Protein(C-6His) 50µg

Synonym

6-phosphofructo-2-kinase/fructose-2;6-bisphosphatase 1; 6PF-2-K/Fru-2;6-P2ase liver isozyme; Fructose-2;6-bisphosphatase; PFKFB1; F6PK; PFRX

Activity

NA

Sequence

Ser2-Tyr471

Fusion tag

C-6His

Accession

P16118

Expressed Host

Human cells

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Purity

＞95% as determined by reducing SDS-PAGE.

Endotoxin

＜1.0 EU per µg as determined by LAL test.

Stability and Storage

Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles

Mol Mass

55.6 kDa

AP Mol Mass

60 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Reconstitution

Please refer to it for detailed information.

Background

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. It belongs to the phosphoglycerate mutase family. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Source

Recombinants or rec. proteins

Group

recombinants