Synonym
CALN;CALNA;CALNA1;CCN1;CNA1;PPP2B
Activity
Using the Octet RED System, the affinity constant (Kd) of human PPPP3CA-His (Cat:13670-H07B) bound to Human PPIA-His was 0.9 nM.
Sequence
Ser2-Gln521
10µg
PKSH030577-10µg
421€
CALN;CALNA;CALNA1;CCN1;CNA1;PPP2B
Using the Octet RED System, the affinity constant (Kd) of human PPPP3CA-His (Cat:13670-H07B) bound to Human PPIA-His was 0.9 nM.
Ser2-Gln521
N-His
Q08209-1
Baculovirus-Insect Cells
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
＞94 % as determined by SDS-PAGE
＜1.0 EU per µg as determined by the LAL method
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
60.8 kDa
60 kDa
Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol
PPP3CA, also known as protein phosphatase 2B, is a member of the PPP phosphatase family, PP-2B subfamily. It is the alpha catalytic subunit of protein phosphatase 2B (PP2B). PP2B is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. It is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems. PPP3CA activates the T cells of the immune system and can be blocked by drugs. It also activates NFATc (a transcription factor) by dephosphorylating it. The activated NFATc is subsequently translocated into the nucleus, where it upregulates the expression of interleukin 2. PPP3CA interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. It also interacts with DNM1L. The interaction dephosphorylates DNM1L and regulates its translocation to mitochondria.
histidine
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Recombinants or rec. proteins
recombinants
